MPSC Pharmacist Gr-B Screening Test-2012 Question paper

MPSC Pharmacist Gr-B Screening Test-2012 Question paper

  1. ‘Xerogel’ refers to

(1) Hydrogel

(2) Dehydrated gel

(3) Gel containing organic solvent

(4) Excess water in gel

  1. Drugs with low therapeutic index have to be cautiously administered since

(1) Their medium toxic dose in high

(2) They are very potent and have low dose

(3) Difference between effective and toxic levels is less

(4) None of the above

  1. The concentration of dextrose isotonic with blood plasma is

(1) 0.9% w/v

(2) 4.5% w/v

(3) 5% w/v

(4) 0.45% w/v

  1. Which of the following is commonly not used for packaging by pharmacists for filling a prescription?

(1) Blister pack

(2) Prescription bottles

(3) Sifter top containers

(4) Dropper bottles

  1. Which of the following is not a method for enhancing transdermal permeation of drugs?

(1) Iontophoresis

(2)  Sonophoresis

(3) Electrophoresis

(4) Hydration of skin

  1. When hypotonic solution is injection intravenously it leads to

(1) Shrinkage of RBCs

(2) Haemolysis of RBCs

(3) Neither shrinkage nor haemolysis

(4) (1) and (2)

  1. A physician requests a 0.1% steroidal cream that is commercially available as a 0.25% strength in a vanishing cream base. Which one of the following ointment bases is the best choice as a diluents in this situation?

(1) Hydrophilic ointment

(2) Vaseline

(3) Lanolin

(4) Cold cream

  1. What does Schedule W of Drugs and Cosmetics Act 1940 and Rules 1945 contain?

(1) List of drugs which shall be marketed under generic name only

(2) Life period of drugs

(3) Standards for cosmetics

(4) Biological and special products

  1. What does DTAB abbreviate for?

(1) Drugs Technology Advisory Board

(2) Directorate of Technological Advisory Board

(3) Directorate of Technical Advisory Board

(4) Drugs Technical Advisory Board

  1. Aqueous coating system for water insoluble polymers are commonly prepared in the form of

(1) Solubilized systems by means of surfactant addition

(2) Solutions with the aid of cosolvents

(3) Pseudo latex system which are colloidal dispersions

(4) None of the above

  1. Computer base PMRs are used for maintaining

(1) Solubilixed system by means of surfactant addition

(2) Solutions with the aid of cosolvents

(3) Pseudo latex systems which are colloidal dispersions

(4) None of the above

  1. Pyrogens which cause a rise in body temperature when injected intravenously are structurally

(1) Bacterial phospholipids

(2) Bacterial lip polysaccharides

(3) Viral DNA

(4) Bacterial glycosides

  1. The degree of flocculation of a suspension is expressed as

(1) Ratio of volume of flocculated sediment to total volume of suspension

(2) Ratio of vo9lume of suspension to volume of flocculated sediment

(3) Ratio of sedimentation volume of flocculated suspension to be sedimentation volume of the suspension when deflocculated

(4) Sediment volume of flocculated suspension

  1. Capping in tablets occurs due to

(1) Defective dies and punches

(2) Damp granules

(3) Excessive fines

(4) (1) and (3)

  1. Toxicity at normal doses of Isoniazid is likely to be due to

(1) Age

(2) Generic factor

(3) Disease state

(4) Renal function

  1. The Drugs Price Control Order4 is passed under

(1) Essential Commodities Act

(2) Drugs and Cosmetics Act

(3) Pharmacy Act

(4) Control of Prices Act

  1. An adverse reaction relatively specific to the use of antibiotics belonging to the class of aminoglycosides is

(1) Ototoxicity

(2) Occular toxicity

(3) Hepatotoxicity

(4) Aplastic anaemia

  1. Which of the following is a non-absorbable suture?

(1) Cat gut

(2) Reconstituted collagen

(3) Polyamide

(4) Kangaroo tendon

  1. Tolerance to one kind of drug that result in tolerance to pharmacologically similar drugs as

(1) Synergistic dependence

(2) Reciprocity

(3) Tolerance threshold

(4) Cross tolerance

  1. An extension of the normal pharmacological effect of a drug or its metabolite is termed as

(1) Type C ADR

(2) Type D ADR

(3) Type A ADR

(4) Type B ADR

  1. While attending to patients during counseling sessions, the desirable body language should be
  2. Facing the patient directly
  3. Leaning forward at a slight angle.

III. Nodding and hand gestures.

  1. Blank stares.

(1) I and II

(2) Only I

(3) I, II and III

(4) I and IV

  1. A potentially life-threatening adverse drug effect may occur due to

(1) Bronchoconstriction in asthmatics due to non-steroidal anti-inflammatory agents

(2) Osteoporosis caused by steroids

(3) Hirsutism induced by Minoxidil

(4) Retinopathy caused by Thioridazine

  1. Positive control in ‘Test for Sterility’ Ensures

(1) The sterility all materials

(2) The nutritive property of medium

(3) The sterility of product

(4) None of the above

  1. As per I.P., for a batch size of 100 numbers (ampoules, vials, etc) of a parenteral product, minimum numbers recommended to be tested for sterility for sterility are

(1) 10% or 4 numbers, whichever is greater

(2) 10% or 6 numbers, whichever is greater

(3) 5% or 2 numbers, whichever is greater

(4) 5% or 3 numbers, whichever is greater

  1. Addition of which of the following to a large volume parenteral product is not advised?

(1) Active pharmaceutical ingredient

(2) Preservatives

(3) Buffering agents

(4) Tonicity adjusters

  1. An ophthalmic solution of a mydriatic drug with a concentration of 5 mg/ml exhibits first-order degradation with a rate of 0.0005 mg/day. Estimate its half life.

(1) 693 days

(2) 1,200 days

(3) 210 days

(4) 1,386 days

  1. Which microbe is used for validation of sterilization by membrane filtration process?

(1) Bacillus stearothermophilus

(2) Pseudomonas aeruginosa

(3) Serratia marcescens

(4) Bacillus subtilis

  1. Morphine Sulphate comes under which Schedule of Drugs and Cosmetics Act?

(1) X

(2) K

(3) H

(4) G

  1. The dosage required to produce a desired pharmacological effect is called

(1) Threshold dose

(2) Dose-response outcome

(3) Effective dose

(4) Maximum dose

  1. In form-fill seal process the essential material used is

(1) Aluminium

(2) Polyacrylate

(3) Paper-metal composite

(4) Polyethylene

  1. Sonication of liposomal product may be related to conversion of

(1) MLV to ULV

(2) SUV to MLV

(3) MLV to SUV

(4) None of the above

  1. Which of the following plots would be most helpful in deciding shelf life at a predetermined temperature?

(1) Remaining under graded vs time

(2) Log remaining under graded vs time

(3) Log rate vs log absolute temperature

(4) Log rate vs inverse of absolute temperature

  1. Which of the following statements regarding polymorphs is true

(1) Polymorphic forms of the same drug are similar and can be substituted in a formulation

(2) Different polymorphic forms of the same drug have identical X-ray diffraction patterns

(3) The metastable polymorphic forms will generally result in a higher dissolution rate

(4) All of the above

  1. A solution of 1 in 2500 strength means

(1) 0.04%

(2) 0.4%

(3) 0.25%

(4) 0.5%

  1. Hixon and Crowell Cube-root law is related to

(1) Micro emulsification

(2) Drug dissolution

(3) Stability of API against hydrolytic degradation

(4) Sedimentation in liquids containing more than 10% suspended particles

  1. The term ‘hydrotrophy’ is used to denote

(1) Water update capacity

(2) Water repulsion capacity

(3) Increase in aqueous solubility due to presence of large amounts of additives

(4) wetting ability

  1. Patients on tranylcypromine therapy are in danger of undergoing a hypertensive crisis on consumption of a cheese eich diet due to

(1) Interaction of tranylcypromine with calcium in cheese

(2) Inhibition of absorption of tranylcypromine by cheese

(3) Presence of antioxidant in cheese

(4) Tyramine content of cheese

  1. An estimate of the water absorption capacity of 100 gms of material as ‘Water number’ is a parameter for evaluation of

(1) Hydrogels

(2) Absorption bases

(3) Gelling agents

(4) Wetting agents

  1. Autoclavable plasticware for repeated sterilization is best fabricated using

(1) Low density polyethylene

(2) Polystyrene

(3) Polyvinyl chloride

(4) Polypropylene

  1. Scalpels and blades for surgery may be sterilized by

(1) Boiling in a water bath

(2) Dry heat sterilization

(3) Membrane filtration

(4) Aseptic technique

  1. Which of the following is added as antioxidant in pharmaceutical dosage forms?

(1) Sorbitan monooleate

(2) Ascorbic acid

(3) Methly cellulose

(4) Sodium saccharin

  1. Shelf life of a pharmaceutical product is computed by

(1) Ficks laws

(2) Arrhenius equation

(3) Higuchi equation

(4) Noyes whitney equation

  1. As per Indian Pharmacopoeia MacConkey agar has

(1) Malachite green

(2) Bromocresol purple

(3) Neutral red

(4) Brilliant green

  1. Gastric emptying is slowed by all of the following, except

(1) Fatty food

(2) Emotional stress

(3) Vigorous exercise

(4) Hunger

  1. A suspension is not a suitable dosage form for

(1) Intra muscular injection

(2) Intra venous injection

(3) Intra articular injection

(4) Intra dermal injection

  1. Hypodermic needle sizes are expressed by gauge numbers. The gauge number refers to the

(1) Bevel size

(2) Internal diameter of the cannula

(3) External diameter of the cannula

(4) size of lumen opening

  1. 330 mg of aspirin is to be filled in hard gelatin capsules. Which is the appropriate capsule size?

(1) 1

(2) 2

(3) 0

(4) 00

  1. The phase inversion temperature (PIT) of a surfactant is one at which

(1) Surfactant forms micelles

(2) Surfactant melts

(3) Hydrophilic and lipophilic properties of surfactant are balanced

(4) Surfactant undergoes inversion

  1. Idiosyncratic reactions to drugs are

(1) Seen only certain individuals

(2) Unrelated with dose of drug administered

(3) Often without explanation of cause

(4) All of the above

  1. What is the shelf life of eyes drops immediately after opening?

(1) 30 days

(2) 90 days

(3) 14 days

(4) 7 days

  1. In the hospitals, the records regarding purchase and distribution of ‘controlled substances’ are to be kept in prescribed format by

(1) Store keeper

(2) Pharmacist

(3) Ward nurse

(4) All of the above

  1. In the test for sterility ‘Fluid Thioglycolate Medium’ is used for detection of

(1)  Aerobic bacteria

(2) Fungi

(3) Aerobic and anaerobic bacteria

(4) Fungi and anaerobic bacteria

  1. The words “It is dangerous to take this preparation except under medical supervision” can be found on lable of drugs belonging to

(1) Schedule X

(2) Schedule H

(3) Schedule C

(4) Schedule G

  1. Excipients that increase the aqueous solubility of poorly soluble drug are

(1) Wetting agents

(2) Solubilizers

(3) Stabilizing agents

(4) Dispersing agents

  1. What should be the air velocity in a horizontal laminar flow work area?

(1) 50 ft/min

(2) 10ft/min

(3) 200 ft/min

(4) 100 ft/min

  1. How many grams of sodium chloride should be used in the preparation of 250 ml of Isotonic Dextrose and Saline solution containing 2.5% w/v of anhydrous dextrose?

(1) 4.5 gms

(2) 1.125 gms

(3) 2.5 gms

(4) 0.9 gms

  1. Which of the following can aggravate pain in prinzmetal variant angina?

(1) Vasodilators

(2) Calcium channel antagonists

(3) B blockers

(4) None of the above

  1. Antihypertensive found safer during pregnancy is

(1) Reserpine

(2) Propranolol

(3) Losartan

(4) Hydralazine

  1. Dimercaprol is a therapeutic antidote against

(1) Heavy metals poisoning

(2) Opiate poisoning

(3) Salicylate poisoning

(4) Pesticide poisoning

  1. Which measure is not used in methanol poisoning?

(1) Folate therapy

(2) Sodium bicarbonate infusion

(3) Ethanol administration

(4) Disulfiram therapy

  1. The drug used in the first line therapy of tuberculosis is

(1) Ethionamide

(2) Ethambutol

(3) Cycloserine

(4) Clofazimine

  1. The reaxctive electrophilic intermediate of Acetaminophen which produces hepatotoxicity is

(1) N-acetyl-para=benzoquinonimine

(2) N-acetyl-ortho-benzoquinonimine

(3) N-methyl-ortho-benzoquinonimine

(4) N-methyl-para-benzoquinonimine

  1. The drug whose side effect has been exploited in the prophylactic treatment of thromboembolic disorders is

(1) Indomethacin

(2) Rofecoxib

(3) Aspirin

(4) Nimesulide

  1. Ionized produces antimycobacterial action by

(1) Inhibiting DNA dependent RNA polymerase

(2) Preventing bacterial protein synthesis

(3) Inhibiting synthesis of mycolic acids

(4) Inhibiting mycobacterial arabinosyl transferases

  1. Human immunodeficiency virus can be transmitted by the following routes

(1) Blood transfusion

(2) Placental transfer

(3) Option (1) and (2) above

(4) None of the above

  1. Sucralfate is used in the treatment of

(1) Hypertansion

(2) Allergy

(3) Diabetes

(4) Ulcers